Ramya Krishna was born on September 15, 1970 in Chennai and by the time she celebrated her 13th birthday she was known as the heroine of Mudal Vasantham. The movie released in 1982 when was a student of Std 8th. She first played the lead role in Vellai Manasu in Tamil opposite Y. Gee. Mahendra.
Though the bollywood directors did not find substance in her. Her looks got her work in South India. She acted in all regional language films of southern part.
Her role as Neelambari in Tamil film Padayappa opposite Rajnikanth brought her recognition and fame not only in South India but also internationally in Japan, Singapore, London and Paris. This film silenced her critics. The film was released in Telugu also as Narasimha.
During a span of twenty five years Ramya Krishnan has acted opposite two generations of Telugu superstars, including Akkineni Nageswara Rao, NT Ramarao, Krishna, Sobhan Babu, Chiranjeevi, Balakrishna, Venkatesh, Akkineni Nagarjuna and Jagapathi Babu.
Like Hindi Movies she has not been lucky with awards. She bagged only one prestigious Nandi Award from the Government of Andhra Pradesh. She also received Film Fare awards twice. In 1999 as Best Actress for Padayappa. Ten years later in 2009 for her film Konchem Ishtam Konchem Kashtam she was judged Best Supporting Actress.
She has settled in Hydrabad after marrying Telugu director Krishna Vamsee in the year 2003. The couple has a son named Ritwik.